Results Of 3575 subjects classified with SLE under at least one system, 3312 (92.6%) were classified as SLE by both systems (SLE both), 85 only by ACR criteria (SLE ACR-only) and 178 only by SLICC criteria (SLE SLICC-only).Of 440 subjects meeting 3 ACR criteria, 33.9% (149/440) were SLE SLICC-only, while 66.1% (n=291, designated ILE) did not meet the SLICC classification criteria. Although the 2012 SLICC criteria addressed some of the shortcomings of the previous ACR criteria (e.g., the addition of mucocutaneous and neuropsychiatric manifestations, hypocomplementemia and anti-nuclear antibody [ANA] tests) and offered more refined criteria definitions, their specificity was lower than the 1997 ACR criteria. SLICC 2012 criteria performed better than EULAR/ACR 2019 criteria. SI. SLICC criteria had increased the sensitivity of ACR criteria Downloaded on December 12, 2020 from www.jrheum.org. Concerning the EULAR/ACR total score cut-off point being compared (whether ≥10 or ≥ 13), application of SLICC criteria still better scored in cut-off point accuracy both at first visit … Reprinted with permission from Bertsias GK, Salmon JE, Boumpas DT. The new 2019 EULAR/ACR classification criteria for SLE requires a positive ANA as obligatory entry criterion. The new SLICC classification criteria performed well in a large set of patient scenarios rated by experts. Results: As shown in Table 1, of the 513 patients with physician validated SLE present in the CLD who satisfied both the ACR and SLICC classification criteria, the ACR-based EHR algorithm detected 79% (398/513) as having SLE, while the SLICC-based algorithm detected 91% (467/513). from 83% to 97% but decreased the specificity from 96% to 84%. Do you agree with the diagnosis of SLE in a young man with leukopenia of 3200/mm3 and 22% of lymphocyte, thrombocytopenia of 76,000/mm3 along with hemoglobin of 9 gr/dl and reticulocyte count of 12% without However, the SLICC 2012 criteria need further external validation. In 2012, the Systemic Lupus International Collaborating Clinics (SLICC) developed and validated new SLE classification criteria.4 The SLICC 2012 criteria performed better than the revised 1997 ACR criteria in terms of sensitivity (97% vs 83%), but were less specific (84% vs 96%).4 SLICC/ACR criteria don't ID severe internal disease in SCLE 27 April 2016 (HealthDay)—Neither the American College of Rheumatology (ACR) nor the Systemic Lupus (SLICC) network, devoted to clinical research in SLE, pre-sented a new set of classification criteria in 2012 (SLICC-12) based on the evaluation of almost 1,400 patient scenar-ios [10]. Data were retrospectively collected, to establish the ACR and SLICC criteria fulfilled, at first visit and within one year of follow-up. Their work included both a derivation and a validation of the new set of criteria as well as of ACR-97. Therapeutic opportunities in systemic lupus erythematosus: state of the art and prospects for the new decade. SLICC criteria but the 2015 ACR/SLICC revised criteria can be fulfilled exactly by it. 62 Other criteria were chosen from 7 clinical (constitutional, hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, renal) and 3 immunologic (antiphospholipid antibodies, complement proteins, SLE-specific antibodies) categories, and weighted from 2 to 10. According to the SLICC rule for the classification of SLE, the patient must satisfy at least 4 criteria, including at least one clinical criterion and one immunologic criterion OR the patient m … In this multicenter cohort, clinical manifestations that could help to distinguish early SLE from SLE- As chair of SLICC Dr. Gladman was a key facilitator in the development and validation of the SLICC/ACR Damage Index. Last year, we performed a similar evaluation of the 2019 EULAR/ACR criteria by using data from Swedish patients of which the majority had Caucasian ethnicity. The SLICC-12 criteria contain additional clinical and 1 The committee set ambitious goals for the new criteria… While achieving their goal of increasing sensitivity, the SLICC criteria have lower specificity than the 1997 ACR criteria 9, 10. Aims Juvenile-onset systemic lupus erythematosus (JSLE) is a severe multi-system inflammatory disease with very varied presentation and disease course. SLICC, Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index. The Systemic Lupus International Collaborating Clinics (SLICC) group proposed revised classification criteria for systemic lupus erythematosus (SLICC-2012 criteria). Misclassified cases. Rheumatology researchers referred to both the 1997 ACR revised criteria and 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria when developing the new criteria, said Martin Aringer, MD, steering committee co-chair and chief of rheumatology at University Medical Center Carl Gustav Carus in Dresden, Germany. Acute cutaneous lupus: lupus malar rash (do not count if malar discoid), bullous lupus, toxic epidermal necrolysis variant of SLE, maculopapular lupus rash, photosensitive lupus rash (in the absence of dermatomyositis). This guideline desc ribes 67 patient characteristics, inclusion and exclusion criteria and concomitant use of other medicines that 68 should be considered in the recruitment phase. Performance of the proposed SLICC criteria compared with the current ACR criteria in the validation sample (n = 690 scenarios)* Rule 1997 ACR criteria Sensitivity Specificity 290/349 (83) 326/341 (96) 0.79 SLICC criteria 340/349 (97) 288/341 (84) 0.82. Performance of the new SLICC classification criteria in juvenile systemic lupus erythematosus, in two observation periods: a Brazilian study 2. SLICC criteria with the 1997 ACR criteria in our juvenile SLE patients. In subse-quent studies in adult and cSLE, SLICC higher sensitiv-ity was also found, especially for early SLE, however, results were conflicting regarding specificity [13–20]. Oral ulcers O r a lo n sph yg euc t i, 5. Ann Rheum Dis 2010;69:1603–11. Our objective was to compare the sensitivity for SLE classification between the ACR 1997 and the SLICC 2012 criteria sets in a real-life, multicenter, international SLE population. The SLICC criteria are validated criteria for making the diagnosis of lupus. The SLICC classification consists of seventeen criteria and for the SLE classification requires: 1) fulfilment of at least four criteria with at least one clinical criterion and one immunologic criterion; or 2) lupus nephritis as the sole clinical criterion in the presence of anti nuclear antibody (ANA) or anti- … The SLICC 2012 criteria yielded the best sensitivity, while the ACR 1997 criteria had the best specificity. The criteria for SLE using ACR 97 requires that the patient present four of the eleven criteria, but the SLICC revised and validated those criteria in 2012 proposing that the patient meet four of the seventeen criteria being at least one clinical criterion and one criterion included in the diagnosis. In the SLICC system, a patient must meet at least four criteria, including at least one abnor-mal clinical criterion and one abnormal SLICC criteria yielded higher sensitivity (97% versus 83%) but lower specificity (84% versus 96%) than ACR 1997 criteria in the original validation set [7]. 66 classification criteria or SLICC SLE criteria should be enrolled in the trials. Separation of different hematological manifestations in the SLICC 2012 criteria might have contributed to the higher performance of this criteria set. Classification criteria have been derived for SLE, mainly for research purposes, to achieve population homogeneity among research studies. If at least four criteria are present, from which at least one is clinical and at least one immunologic. Nine (10.6%) met ≥4 SLICC clinical criteria, but were excluded by SLICC cri-teria due to an absence of immunological criteria. Loss of SLE classification by SLICC criteria was primarily due to the combination of malar rash and photosensitivity into a single SLICC criterion (53/85; 62.4% of 1. Although both ACR and SLICC criteria are used in SLICC criteria (figure 1A, top). The Systemic Lupus Collaborating Clin-ics (SLICC) international group undertook the evaluation Lupus nephritis as sole clinical criterion in the presence of ANA or anti-dsDNA antibodies. Nonerosive arthritis I nv o li g≥2 p erh aj t s, wd 6. Discoid rash Raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3. SLICC criteria is considered positive in two cases: 1. B Photosensitivity yp atie nh s orc b v 4. validated the ACR criteria. Conclusion. Collaborating Clinics (SLICC) network presented a set of criteria based on almost 1400 patient scen-arios, including a derivation and a validation of the new criteria as well as of the 1997 ACR classifica-tion.2,3 Compared with the 1982 and 1997 ACR cri-teria, SLICC-12 contains additional clinical and 74. Overall, it resulted in a lower number of misclassified cases5. Methods. We concluded that SLICC-12 had advantages compared with older criteria with regard to diagnostic sensitivity, whereas we found the diagnostic specificity to be surprisingly low.3. SLICC criteria exhibited higher global accuracy at both observation periods. Table 6. Methods Cases were JSLE and controls were patients with other rheumatic diseases, attending a tertiary center in the past 10 years. General Calculators. Malar rash F lat or i se dy hm , fnp g b 2. The American College of Rheuma-tology (ACR) published criteria in 1982, which were revised in 1997 (Table 1). 13. Clinical Criteria Acute Cutaneous Lupus OR Subacute Cutaneous Lupus. We thank Rönnelid et al for their comments on our paper, ‘Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes, and ethnicities.’1 In 2019, the authors comparatively evaluated the ‘diagnostic accuracy’ of the 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) systemic … Acceptable endpoints should be used in order to assess 69 efficacy. early SLE were not identified as having early SLE with use of the SLICC criteria compared to the ACR criteria (16.5% versus 33.9%), but the ACR criteria demonstrated higher specificity than the SLICC criteria (91.6% versus 82.4%). Imperial. Wd 6 positive in two Cases: 1 fulfilled, at first visit within... Collaborating Clin-ics ( SLICC ) group proposed revised classification criteria for making the diagnosis of.... 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