spleen [splēn] a large glandlike but ductless organ in the upper part of the abdominal cavity on the left side, lateral to the cardiac end of the stomach. The spleen sits under your rib cage in the upper left part of your abdomen toward your back. Spleen definition: Your spleen is an organ near your stomach that controls the quality of your blood. Called also lien. Spleen Definition. Inside, the mass of splenic tissue is of two types, the red pulp and the white pulp, which do not separate into regions but intermingle and are distributed throughout the spleen. Most people chose this as the best definition of spleen: The spleen is an organ ne... See the dictionary meaning, pronunciation, and sentence examples. Medical Definition of Spleen Medical Author: William C. Shiel Jr., MD, FACP, FACR Spleen: An organ that is located in the upper-left part of the abdomen, not far from the stomach, that produces lymphocytes, which are important elements in the immune system. Enlargement of the spleen is treated by addressing the underlying illness. Information and translations of spleen in the most comprehensive dictionary definitions resource on the web. This can lead to removal of the spleen. adj., adj splen´ic. The spleen also stores blood — the blood vessels of the spleen can expand significantly. An enlarged spleen can be detected by physician examination or via diagnostic imaging. If your spleen ruptures due to a severe abdominal injury or because of an enlarged spleen (splenomegaly), the result may be life-threatening, internal bleeding. The lymphatic system is the system of ducts and lymph nodes which are found under the skin. Learn more. Definition of spleen in the Definitions.net dictionary. ‘These lesions have been reported in the brain, 3 lymph nodes, 4 spleens, 5 lungs, 6 and several other sites.’ ‘The lateral approach provides an excellent view of … Splenectomy may be done to ease the symptoms of an enlarged spleen, which include pain and a feeling of fullness. The spleen can also become injured or rupture immediately after a hard hit to the abdomen, a rib fracture, or other accident. Meaning of spleen. Enlarged spleen. The spleen is a small organ, typically located on the left side of the body, behind the ribcage and stomach.It is the largest organ in the body’s lymphatic system, which is responsible for promoting immune function, filtering the blood, and managing blood volume.. This enlargement is a result of an excess of trapped blood cells that can damage the spleen's function. 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