We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. • Part of mononuclear phagocyte system. Schema of a venous sinus located in the cords of the red pulp. Presentation 11 Aida1983. The spleen is an organ found in virtually all vertebrates.Similar in structure to a large lymph node, it acts primarily as a blood filter.The word spleen comes from Ancient Greek σπλήν (splḗn).. The spleen reaches peak development at puberty, in rats, followed by gradual involution (Losco, 1992).
It’s protected by the rib cage. WebMD's Spleen Anatomy Page provides a detailed picture, definition, and information about the spleen. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Blood from the cords collects in the sinuses (shown by arrows). The human spleen is surrounded by a capsule of dense connective tissue containing relatively little muscle and therefore incapable of the extensive contraction exhibited by the muscular capsule of the spleen in dogs and cats. The WP is the primary immunologic region of the spleen in both species; however, the WP makes up less than a quarter of splenic tissue. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. The largest lymphoid organ , it sites of lymphocyte proliferation and … Structure and function of Spleen 1. 3-the splenocolic, which connects the spleen to the colic flexure and to the thoracic diaphragm. The mesenchymal cells differentiate into the parenchymal cells, connective tissue and the surface capsule. You can change your ad preferences anytime. An enlarged spleen can be detected by physician examination or via diagnostic imaging. 4-the splenophrenic, which connects the spleen to the diaphragm. 1- Cleanses the blood by removing old RBCs and platelets, as well as debris from the blood. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The peritoneum is closely adherent to the outside of the capsule. Similar in structure to a large lymph node, it acts primarily as a blood filter. Thus, the spleen is situated between the fundus of the stomach and the diaphragm. 9 The spleen plays important roles in regard to red blood cells (erythrocytes) and the immune system. The spleen is in the portal circulation. Location and Structure of Spleen 2. The spleen can become enlarged as a result of infection, anemia or cancer. The venous sinuses consist of a lining of endothelial cells that are positioned in parallel and connected by stress fibres to annular fibres, which are composed of extracellular-matrix components. In a trauma patient with an injury to the abdomen, the most common symptoms of a ruptured spleen are pain and tenderness of the abdomen, particularly on the left upper quadrant. Because the red-pulp cords contain a large number of macrophages, ageing erythrocytes that are no longer able to pass through the slits are phagocytosed. , and is directed upward, backward, and to the left, except at its upper end, where it is directed slightly medially. As blood enters the abdominal cavity, it can lead to a symptom known as referred pain. A considerable amount of literature has accumulated since that time, in which the authors dealing with different classes of Vertebrata, and even those who have studied the question in the same animals, have arrived at widely differing conclusions. If you continue browsing the site, you agree to the use of cookies on this website. The spleen is located in the upper-left part of the abdomen. The red blood cells can be released when needed. the spleen is secured by four suspensory ligaments ; 1-the gastrosplenic, which connects the stomach to the spleen. of areolar plane. Basic structure of the spleen Although it varies in size between individuals, a spleen is typically around 3–5.5 inches long and weighs 5.3–7.1 ounces (oz). Structure and function of spleen- anatomy, physiology. The Spleen Anatomy Of Spleen White Pulp Spleen Structure The White PPT. This function, in combination with a highly organized lymphoid compartment, makes the spleen the most important organ for antibacterial and antifungal immune reactivity. Lies between body and neck of gallbladder 2. • Lymphatic organ connected to blood vascular system The lymphatic system is the system of ducts and lymph nodes which are found under the skin. The spleen is an organ shaped like a shoe that lies relative to the 9th and 11th ribs and is located in the left hypochondrium and partly in the epigastrium. The capsule is deeply indented at the medial aspect of the organ and this indentation is known as hilus (hilum) of the spleen. With the spleen retracted medially, the phrenicocolic ligament is incised. Procedures Aida1983. Bone marrow is the soft, flexible connective tissue within bone cavities. Lymphoma is the most common malignancy affecting the spleen and may be primary or secondary. The spleen is a large, encapsulated, bean-shaped organ that is situated on the left side of the body below the diaphragm. A component of the lymphatic system, bone marrow functions primarily to produce blood cells and to store fat.Bone marrow is highly vascular, meaning that it is richly supplied with a large number of blood vessels.There are two categories of bone marrow tissue: red marrow and yellow marrow. Location and Structure of Spleen: Spleen lies in between the fundus of the stom­ach and the diaphragm. Grossi, P.M. Lydyard, in Encyclopedia of Immunology (Second Edition), 1998. If you continue browsing the site, you agree to the use of cookies on this website. Functions of the spleen . See our User Agreement and Privacy Policy. 2- Stores the breakdown products of RBCs site of erythrocyte production in the fetus. Structure of the spleen. Looks like you’ve clipped this slide to already. Spleen- Structure and Functions. Pott's disease- tuberculosis of the spine, An approach to a child with hepatosplenomegaly and lymphadenopathy, Customer Code: Creating a Company Customers Love, No public clipboards found for this slide. This enlargement is a result of an excess of trapped blood cells that can damage the spleen's function. Some have believed the spleen to be derived from the mesenchyme of the dorsal mesentery, with or without the participation of the coelomic epithelium; s… The structure of the spleen enables it to remove older erythrocytes from the circulation and leads to the efficient removal of blood-borne microorganisms and cellular debris. The reason for this is unknown but may relate to the fact that lower blood pressure allows less rapid flow and minimizes damage to normal erythrocytes. The spleen is an organ located in the upper left abdomen, and is roughly the size of a clenched fist. Spleen • Lymphatic organ connected to blood vascular system • Part of mononuclear phagocyte system. C.E. All the efferents pass into the intestinal lymph trunks, which then enter the cisterna chyli or the abdominal confluence of lymph trunks. Dreamy249. The splenic artery enters the spleen at the hilus, then that run through the parenchyma or pulp of the spleen. In dogs, the spleen increases in weight during the first 6 months of life (HoganEsch and Hahn, 2001). The spleen is the largest secondary immune organ in the body and is responsible for initiating immune reactions to blood-borne antigens and for filtering the blood of foreign material and old or damaged red blood cells. 1 At presentation, the spleen is involved in up to 40% of patients with Hodgkin’s disease (HD) and non-Hodgkin’s lymphoma (NHL), and this increases to 70% at postmortem.1, 2, 3 Accurate assessment of the spleen in lymphoma is important because it can alter tumor staging, influence … See our User Agreement and Privacy Policy. The spleen is the largest single mass of lymphatic tissue in the body. Spleen is located in left upper part of abdomen or hypochondrium. Cells of reticulum do not stain deeply with carmine, and in this respect differ from the cells of the Malpighian corpuscles. Now customize the name of a clipboard to store your clips. End of 1 part of doudenum , begins of 2nd part of doudenum Neck - Form the cystic duct, 4cm Hartmann’s Pouch 1. The spleen is an organ found in virtually all vertebrates. … The spleen is the largest accumulation of lymphoid tissue in the body. In humans, up to a cup (236.5 ml) of red blood cells can be held in the spleen and released in cases of hypovolemia. The long axis lies along the shaft of the 10th rib, and extends forward only as far as the midaxillary line and cannot be palpated on clinical examination. • Wedge shaped 2. Tuftsin binds to specific receptors on the surface of macrophages and polymorphonuclear leukocytes, stimulating their migration, phagocytic, bactericidal, and tumoricidal activity. The spleen is encased in a thick connective-tissue capsule. The spleen contains T and B lymphocytes as well as many phagocytes and is a major component of the mononuclear phagocyte system. The Thymus: Gross Specimen Thymic Structure Thymus ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 3bf4ef-MTM1Z It lies just beneath the left half of the diaphragm close to the 9th, 10th, and 11th ribs. Find PowerPoint Presentations and Slides using the power of XPowerPoint.com, find free presentations research about Function And Structure Of Spleen PPT 2-the splenorenal, which connects the spleen to the kidney. The spleen is delivered to the midline by means of blunt and sharp dissection of the areolar plane between the kidney and the pancreas. Presentation Summary : The Spleen Anatomy of Spleen White Pulp Spleen Structure The white pulp is circular in structure and is made up mainly of lymphocytes. Now customize the name of a clipboard to store your clips. Normal Structure, Function, and Histology of the Spleen MARK F. C ESTA Integrated Laboratory Systems, Inc., Durham, North Carolina 27713, USA ABSTRACT The spleen is the largest secondary immune organ in the body and is responsible for initiating … Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. See our Privacy Policy and User Agreement for details. Obliquely along 10 rib, directed downwards, forwards and lat. It can store platelets in case of an emergency. The spleen is very vascular and reddish purple in color; its size and weight vary. The stress fibres run along the long axis of the endothelial cells and are most prominent where the endothelial cells are in contact. The spleen. Numerous references discuss the effects of aging on lymphocyte function and changes in the distribution of lymphocyte subsets. The spleen is a small organ, typically located on the left side of the body, behind the ribcage and stomach.It is the largest organ in the body’s lymphatic system, which is responsible for promoting immune function, filtering the blood, and managing blood volume..
WHERE IS THE SPLEEN LOCATED
... Thymus gland ppt. Spleen is covered by a connective tissue capsule which is again enveloped by a serous membrane, the peritoneum. It also influences antibody formation. In the adult, the spleen functions mainly as a blood filter, removing old red blood cells. Spleen • situated principally in the left hypochondriac region, but its superior extremity extends into the epigastric region 3. Contractility of the stress fibres allows the formation of slits between the endothelial cells, thereby regulating the passage of blood and blood cells from the red-pulp cords into the sinuses and back into the venous system. Clipping is a handy way to collect important slides you want to go back to later. It also plays a role in both cell-mediated and humoral immune responses. Learn about its function, location in the body, and conditions that can affect the spleen. The spleen is surrounded by a capsule of dense connective tissue from which emerge trabeculae, which divide the parenchyma, or splenic pulp, into incomplete compartments.Large trabeculae originate at the hilum, on the medial surface of the spleen; these trabeculae carry nerves, arteries and veins. Spleen Clinicas Quirurgicas. The spleen is divided by function and structure into the red pulp (RP) and white pulp (WP); in between these two regions is the marginal zone (MZ) in rodents and the perifollicular zone in humans (1, 2). It functions in a manner. Figure 19. Spleen Definition. View and Download PowerPoint Presentations on Function And Structure Of Spleen PPT. Thymus & Spleen Sarah Murray sgm2106@columbia.edu November 30, 2005 Are you getting immune to exam blocks yet?? Up to a quarter of lymphocytes can be stored in the spleen at any one time, 1. Fractures Aida1983. The question of the origin and early development of the spleenhas been the object of researches since the year 1867. Germinal centre Bcells are surface IgD2, while mantle zone B cells coexpress IgM and IgD. Clipping is a handy way to collect important slides you want to go back to later. Open splenectomy: incision of phrenicocolic ligament. The spleen is soft, highly vascular and dark purple in colour. Blood Circulation in Spleen 3. Spleen spleen. Looks like you’ve clipped this slide to already. liver—about 1.4 l (about 3 pt) every minute, Formed at hilum, straight course behind pancreas, Trabecular veinsTrabecular arteriesPulp veinsPenicillar arteriolesFollicle with follicle capillariesArtery with periarterial lymphatic sheath (PALS) 78910Splenic sinusReticular fibrous frameworkOpen capillariesClosed capillaries. Inside, the mass of splenic tissue is of two types, the red pulp and the white pulp, which do not separate into regions but intermingle and are distributed throughout the spleen. • Wedge shaped. The spleen functions as a hematopoietic center until late fetal life. See our Privacy Policy and User Agreement for details. The structure of the spleen enables it to remove older erythrocytes from the circulation and leads to the efficient removal of blood-borne microorganisms and cellular debris. Structure of GB Fundus -Ant:ant.abdominal wall - Post.inf: transverscolon Body sup: liver stpost.inf: Tr.colon. Last Updated on January 11, 2020 by Sagar Aryal. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. You can change your ad preferences anytime. This is pain that the patient feels somewhere other than where the injury is located. Spleen Aida1983. No public clipboards found for this slide. If you continue browsing the site, you agree to the use of cookies on this website. Since the spleen is so rich with blood flow, bleeding from a rupture can be signi… Functions. If you continue browsing the site, you agree to the use of cookies on this website. 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